Quercetin protects human brain microvascular endothelial cells from fibrillar β-amyloid1–40-induced toxicity

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Quercetin protects human brain microvascular endothelial cells from fibrillar β-amyloid1–40-induced toxicity

Amyloid beta-peptides (Aβ) are known to undergo active transport across the blood-brain barrier, and cerebral amyloid angiopathy has been shown to be a prominent feature in the majority of Alzheimer׳s disease. Quercetin is a natural flavonoid molecule and has been demonstrated to have potent neuroprotective effects, but its protective effect on endothelial cells under Aβ-damaged condition is un...

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ژورنال

عنوان ژورنال: Acta Pharmaceutica Sinica B

سال: 2015

ISSN: 2211-3835

DOI: 10.1016/j.apsb.2014.12.003